Michael J. Paidas, MD

Professor of Obstetrics, Gynecology, and Reproductive Sciences; Vice Chair, Obstetrics; Program Director, Maternal Fetal Medicine Fellowship; Director of the Yale Women and Children's Center for Blood Disorders and Preeclampsia Advancement; Co-Director, National Hemophilia Foundation - Baxter Clinical Fellowship Program at Yale; Division of Maternal Fetal Medicine

Departments & Organizations

Obstetrics, Gynecology & Reproductive Sciences: Endometrial Hemostasis/Thrombosis and Angiogenesis Unit | Maternal-Fetal Medicine: Clinicians; High-Risk Pregnancy Program; Maternal Special Care Unit; Prenatal Diagnostic Service; Recurrent Pregnancy Loss Program | Perinatal Research | Women and Children's Center for Blood Disorders, Yale

Office of Student Research

Prenatal Laboratory

Yale Medical Group

Biography

Michael J. Paidas, M.D. is Professor of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine; Interim Chief, Section of Maternal Fetal Medicine; Interim Director, Maternal Fetal Medicine Fellowship; Interim Chief, Obstetrical Service, YNHH; Co-Director of the Yale Women and Children’s Center for Blood Disorders, and Co-Director of the National Hemophilia Foundation-Baxter Clinical Fellowship at Yale.

Dr. Paidas is the recipient of The David J. Leffell, M.D. Prize for Clinical Excellence at Yale in 2010, given to one member of the Yale Medical Group annually. In 2012, Dr. Paidas received the Dean’s Award from the Tufts Medical Alumni Association. Dr. Paidas is included in the top 1% physician by specialty in the nation according to US News and World Report. He has been recognized by the March of Dimes and is included in Best Doctors in America. Dr. Paidas has also received the National Faculty Award by the Counsel on Resident Education in Obstetrics and Gynecology.

Dr. Paidas received his medical degree from Tufts University School of Medicine in 1987 and completed his internship and residency in Obstetrics and Gynecology in 1991 at Pennsylvania Hospital. In 1993, Dr. Paidas completed a Fellowship in Maternal Fetal Medicine at the Mount Sinai School of Medicine in New York. In 2013, Dr. Paidas was awarded a Master of Arts, Honorary Degree, from Yale University.

Dr. Paidas's career in medicine has focused on women’s health with special emphasis on blood disorders, reproduction, pregnancy complications and the latter’s impact on health and disease. His activities span direct patient care, translational research and clinical trials. Dr. Paidas’s research has been supported by federal and non- federal funding agencies. His notable contributions include: description of the regulatory factors of the Protein C system; clinical use of recombinant antithrombin in disease states; elucidation of the subsequent cardiovascular and non-cardiovascular health consequences of hypertensive disorders and preterm delivery in the largest population based studies published to date.

Dr. Paidas and collaborators have described the genomic and proteomic effects of Preimplantation Factor (PIF), a novel mammalian embryo derived factor which regulates maternal receptivity to pregnancy and possesses key immune modulatory properties. Subsequent animal studies using a synthetic analogue of native PIF have shown benefit in animal models related to a variety of immune diseases, including multiple sclerosis and graft versus host disease.

Dr. Paidas is the lead Prinicipal Investigator of a multicenter preeclampsia treatment clinical trial, entitled Prospective Randomized Double-Blind, Placebo Controlled Evaluation of the Pharmacokinetics, Safety and Efficacy of Recombinant Antithrombin Versus Placebo in Preterm Preeclampsia (PRESERVE-1).

Dr. Paidas has expertise in prenatal ultrasound, invasive fetal diagnostic and therapeutic procedures. His academic profile includes over 500 published manuscripts, abstracts, books, chapters, presentations or courses.

Education & Training

MA Yale University, Honorary Degree (2013)
MD Tufts University School of Medicine (1987)
BS Fairfield University (1982)
Resident Pennsylvania Hospital
Fellow Mount Sinai Medical Center

Honors & Recognition

  • Distinguished Alumni at 25th Class Reunion, Tufts University School of Medicine (speaker)Tufts University School of Medicine (2012)

  • Distinguished Alumni at 25th Class Reunion, Tufts University School of Medicine (speaker)Tufts University School of Medicine (2012)

  • US News and World Report, Top 1% Physician In Nation (by specialty)US News and World Report (2012)

  • America's Top Doctor, Castle Connolly, 11th EditionCastle Connolly (2012)

  • US News and World Report, Top 1% Physicians In NationUS News and World Report (2012)

  • New York Magazine, Best Doctors, Castle ConnollyNew York Magazine (2012)

  • Tufts Medical Alumni Association, Dean's Award, RecipientTufts University School of Medicine (2012)

  • Board of Permanent Officers, Yale University School of MedicineYale University School of Medicine (2012)

  • The David J. Leffell, M.D. Prize for Clinical Excellence at Yale Yale School of Medicine (2010)

  • The National Institutes of Health and the Canadian Institutes of Health Research, 5th Annual Summer Institute in Maternal- Fetal Pharmacology, La Sapiniere, Val-David, Quebec, graduateNICHD and CIHR (2009)

  • National Faculty Award, CREOGCREOG (2009)

  • Co-Director National Hemophila Foundation - Baxter Clinical Fellowship at YaleNational Hemophilia Foundation (2009)

  • National Hemophilia FoundationMedical Advisory Board Member (2009)

  • Hemostasis and Thrombosis Research SocietyResearch Subcommittee Member (past - Board of Director) (2008)

  • Best Doctors, New York MagazineNew York Magazine (2007)

  • Flagship Referral Network Member (2006)

  • Best Doctors in AmericaBest Doctors in America (2005)

  • MemberAmerican Society of Hematology (2004)

  • The New York Obstetrical Society, FellowThe New York Obstetrical Society (2000)

  • Frontiers in Reproduction: Molecular and Cellular Concepts and Applications. Marine Biological Laboratory, Woods Hole graduateNICHD (1998)

  • Bellevue Obstetrical and Gynecological Society, MemberBellevue Obstetrical and Gynecological Society, New York University (1998)

  • Teaching AwardTufts University School of Medicine (1995)

  • Globus Award, Prize Paper for 1994The Mount Sinai Journal of Medicine (1995)

  • 4th Annual NICHD Aspen Conference, participantNICHD (1992)

  • S. Leon Israel Prize Paper AwardPhiladelphia Obstetrical Society (1991)

  • Thomas R. Boggs Award - Outstanding Obstetrical Resident in Intensive Care Nursery Pennsylvania Hospital (1988)

  • Alpha Epsilon Delta, TreasurerAlpha Epsilon Delta, Fairfield University (1982)

  • Headmaster’s Scholarship, Fairfield UniversityFairfield University (1978)

Professional Service

  • Contributor Society for Maternal Fetal Medicine (2009)

  • Rare Bleeding Disorder Committee, Centers for Disease Control, member Center for Disease Control (2003 - 2013)

  • Scientific Advisory Committee, member, International Stillbirth Alliance International Stillbirth Alliance (2007)

  • Fetal and Infant Mortality Review (FIMR) of Greater New Haven, member Centers for Disease Control (2003)

  • American College of Obstetricians and Gynecologists: Task force on Pulmonary Embolism in Pregnancy, Representative American College of Obstetricians and Gynecologists (2007)

  • Participant, NHLBI Workshop: Bridging Preeclampsia and Future Cardiovascular Disease. Sponsored by Department of Health and Human Services, National Institutes of Health, National Heart, Lung and Blood Institute. September 16-17, 2010. 6701 Rockledge Drive, Bethesda, MD, Room 10091 NHLBI Workshop (2010)

  • Working Group on Mechanistic Perspectives on Hormone-Induced Thrombosis in Women, sponsored by NIH/NIHLBI. Presenter. Sept 13-14, 2012 NIH/NIHLBI (2012)

  • “Pregnancy Outcomes as Predictors of Cardiovascular Disease Risk Factors” April 16, 2013 National Heart, Lung, and Blood Institute Special Emphasis Panel (2013)

  • Society for Maternal Fetal Medicine and American College of Obsetrician Gynecologists Working Group for Deep Venous Thrombosis Prevention Patient Safety Bundle. 61st Annual Clinical Meeting, The American College of Obstetricians and Gynecologists Society for Maternal Fetal Medicine and American College of Obstetrician Gynecologists (2013)

  • National Institutes of Health, invited member of a voluntary registry for reviewers National Institutes of Health (2008)

  • Randomized Controlled Trials Committee, CIHR (Canadian Institutes of Health Research), Invited Reviewer Canadian Institutes of Health Research (2005)

  • Society for Gynecologic Investigation, Member Society for Gynecologic Investigation (2006)

  • New Haven Obstetrical Society, Member New Haven Obstetrical Society (2002 - 2014)

  • Society for Maternal Fetal Medicine, Member Society for Maternal Fetal Medicine (1991 - 2014)

  • American College of Obstetricians and Gynecologists, Fellow American College of Obstetricians and Gynecologists, (1988 - 2014)

  • American Institute of Ultrasound in Medicine American Institute of Ultrasound in Medicine (1996 - 2014)

  • Annual Summer High School Scholars Program at Yale Women and Children's Center for Bood Disorders Yale Women and Children's Center for Bood Disorders (2002)

  • Mentor for Jacob Lykke, M.D., Ph.D candidate, Yale Women and Children’s Center for Blood Disorders Department of Obstetrics, Gynecology and Reproductive Sciences Yale University School of Medicine. Thesis dissertation: ‘Adverse outcome and subsequent cardiovascular disease’ Yale Women and Children’s Center for Blood Disorders (2007 - 2008)

  • Mentor for Nazli Hossain, MBBS, FCPS, Visiting Associate Professor Yale Women and Children’s Center for Blood Disorders Yale Women and Children’s Center for Blood Disorders (2006 - 2007)

  • Mentor for Gabriele Urban, M.D., from Department of Obstetrics and Gynecology at the University of Milano Bicocca, Italy, as Visiting Research Fellow Department of Obstetrics, Gynecology, Reproductive Sciences, Yale (2005 - 2006)

  • Mentor for Pietro Barretta, 4th year medical student, Univ. Milan, Bicocca. Thesis: Multigate Doppler and Prediction of Adverse Pregnancy Outcome. Yale Womena and Children's Center for Blood Disorders (2008 - 2008)

International Activity

  • “Preimplantation factor (PIF): a biomarker for viable embryo selection after in vitro fertilization and for pregnancy outcome.” Poissy, France; Athens, Greece; New Haven, United States (2012)

    This proposal is a multicenter study which investigates the potential role of Preimplantation Factor as a diagnostic test in two settings; namely, to predict IVF success when measured in embryo culture media, and to predict viable pregnancy and a range of placenta mediated complications.

    ... ...

  • Textbook: Hemostasis and Thrombosis in Obstetrics and Gynecology Oxford, United Kingdom (2011)

    Blackwell Publishing, first edition, 2011. Editors: Paidas Michael J., Hossain Nazli, Shamsi Tahir, Rodger M, Langhoff-Roos Jens, Lockwood Charles J. Wiley Blackwell, Oxford, OX4 2DQ, UK

  • “NOICH study”: This study is an international study to determine the breath and experience of antenatal treatment of alloimmune thrombocytopenia. Leiden, Netherlands (2008)

    Research collaboration to determine the optimal management of alloimmune thrombocytopenia during pregnancy

  • Biomarkers for the detection of pregnancy complications, role of anticoagulation in the prevention of placenta mediated complications, use of recombinant factor VIIa to treat postpartum hemorrhage Karachi, Pakistan (2006)

    Research collaboration to investigate causes, prevention strategies and treatment regimens for pregnancy complications, especially preeclampsia and postpartum hemorrhage in a developing country

  • Adverse Pregnancy Outcome, Subsequent Cardiovascular Copenhagen, Denmark (2004)

    Research collaboration to investigate risk factors for pregnancy complications and subsequent maternal health consequences

  • Multigate Doppler with Global Acquisition and Signal Processing (G.A.S.P.) in the uteroplacental, fetal circulations and gynecologic ultrasound. Florence, Italy; Milan, Italy (2001)

    Research collaboration to develop and implement an improved, non-invasive Doppler ultrasound technique

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Contact Info

Michael J. Paidas, MD
Patient Care Locations
Lawrence & Memorial Hospital
365 Montauk Avenue

New London, CT 06320
Waterbury Hospital
64 Robbins Street

Waterbury, CT 06708
Maternal-Fetal MedicineYale-New Haven Hospital
20 York Street, Ste East Pavillion 4th floor

New Haven, CT 06510
Yale-New Haven Hospital Saint Raphael Campus
1450 Chapel Street

New Haven, CT 06511
Yale Maternal-Fetal Medicine Center1 Long Wharf Drive, Ste 2nd Floor
New Haven, CT 06511
Mailing Address
PO Box 208063
New Haven, CT 06520-8063