Arya Mani, MD, FACC, FAHA

Associate Professor of Medicine (Cardiology) and of Genetics; Director, Cardiovascular Genetics Program; Director, Cardiovascular Module

Departments & Organizations

Internal Medicine: Cardiovascular Medicine: Advanced Imaging Program; Cardiomyopathy Inherited Cardiovascular Disease Program; Cardiovascular Genetics Program; Mani Lab | Liver Center


Heart & Vascular Center, Yale-New Haven Hospital

Office of Student Research

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Molecular Cell Biology, Genetics and Development: Cell Biology; Development; Genetics and Genomics; Human Disease; Molecular Mechanisms; Signal Transduction

Yale Medical Group

Office of Cooperative Research


As the Director of the Cardiovascular Genetics Program at Yale, I run a weekly outpatient clinic where I am involved in evaluation and management of patient with inherited cardiovascular diseases, supervision of the cardiovascular genetic counselor in providing consult to patients with inherited cardiovascular disease and in genetic testing, data analysis and diagnosis of the genetic disorder in these patients. I have established the first center for center for comprehensive testing of disease genes using the state of the art technology known as whole exome sequencing. We evaluate patients wih inherited arrhythmias, sudden cardiac death, Long QT syndrome, Brugada, Cardiomyopathy, inerited aortic diseases, coronary artery disease and lipid abnormalities and many othe inherited heart disease. We also manage the therapy of patients with lipid disorder, metabolic syndrome and coronary artery disease. We are the only center that has identified the cause of hereditary metabolic syndrome.

Education & Training

MD Johannes-Gutenberg-University of Mainz (1991)
Fellow Yale University School of Medicine
Resident Yale-New Haven Hospital
Fellow University of Erlangen-Nuernberg
Board Certification AB of Internal Medicine, Internal Medicine (1996)
Board Certification The Certification Board of Nuclear Cardiology, Nuclear Cardiology (2000)
Board Certification AB of Internal Medicine, Cardiovascular Disease (2001)
Board Certification National Board of Echocardiography, Adult Transthoracic Plus Stress Echocardiography (2008)

International Activity

  • The genetic etiology of coronary artery disease Mumbai, India (2001)

    Identification of genetic causes of premature coronary artery disease in South Asians

  • Genetics of Cardiovascular Diseases Isfahan, Iran; Shiraz, Iran; Tehran, Iran (1998)

    Study of genetic causes of coronary artery disease and congenital heart defect

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Contact Info

Arya Mani, MD, FACC, FAHA
Patient Care Locations
Yale Nuclear CardiologyYale-New Haven Hospital
20 York Street

New Haven, CT 06510
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Yale CardiologyYale Physicians Building
800 Howard Avenue, Ste 2nd floor

New Haven, CT 06519
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Lab Location
Mani's Lab300 George Street, Ste 759
New Haven, CT 06511
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Mailing Address
PO Box 208056
333 Cedar Street

New Haven, CT 06520-8056